Cardiovascular diseases, allergies and immunity, brain development and dysfunction, urinary system diseases, etc
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.All assisted reproduction families are accepted; 2.Pregnant women >=38 years of age are accepted; 3.Receiving pregnant women with low A during pregnancy (serum TSH concentration between 4.0 and 10mlU/L); 4.Pregnant fetuses, infants and young children with abnormal results indicated by blood tests and B-ultrasound during pregnancy (including intrauterine growth restriction, abnormal growth and development of various organ systems, etc.); 5.Accept families with multiple children; 6.Preterm infants born before 35 weeks are accepted; 7.Female age >=20 years old, male age >=22 years old, offspring <=3 years old; 8.Neither parent has HIV, other sexually transmitted diseases and other infectious diseases, and there is no family history of hereditary diseases such as Down syndrome; 9.Both parents agreed to participate and cooperate with long-term follow-up; 10.Sign informed consent before the project research, and have a full understanding of the research content, process and possible adverse reactions, and be able to communicate well with researchers.
Exclusion criteria
Exclusion criteria: 1.Participants deemed unsuitable for this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Congenital heart disease;anaphylactic disease;Brain development and dysfunction;Urology disease; | — |
Countries
China
Contacts
The Second Affiliated Hospital of Wenzhou Medical University