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Effect of Antibiotics Local Application Assisted with VSD after DAIR on Periprosthesis Joint Infection:A Retrospective Study

A retrospective study on the effect of local antibiotics in joint cavity on the outcome of periprosthetic joint infection after debridement with prosthesis preservation assisted by vacuum sealing drainage

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096144
Enrollment
Unknown
Registered
2025-01-20
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periprosthesis Joint Infection

Interventions

DAIR group:None
DAIR with vacuum sealing drainage (VSD) and intra-articular antibiotic infusion group:None

Sponsors

Shanghai Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
8 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1) Infection occurring within 4 weeks of primary joint replacement, or infection occurring within 4 weeks of a previously well-functioning joint. 2) The results of pathogen examination were clear. 3) There were high clinical manifestations of infection with fever, chills, sinus, pus, pain, skin temperature rise. 4) Patients treated with local antibiotic therapy or simple debridement in joint cavity with the assistance of negative pressure closed drainage after debridement with prosthetic retention. 5) Follow-up for more than 1 year.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1) The case lacked relevant medical history. 2) No clear pathogenic results were found. 3) Infection caused by other sites after orthopedic surgery (such as urinary tract infection, intravenous catheter infection, etc.). 4) Patients receiving other forms of treatment. 5) The follow-up time was less than 1 year.

Design outcomes

Secondary

MeasureTime frame
Erythrocyte sedimentation rate, ESR;C-reactive protein;Joint function score;

Primary

MeasureTime frame
Recurrence of infection;

Countries

China

Contacts

Public ContactHao Shen

Shanghai Sixth People's Hospital

shenhao7212@sina.com+86 189 3017 7367

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026