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Comparing the efficacy of active surveillance versus adjuvant chemotherapy after fertility-sparing surgery in patients with stage I ovarian immature teratomas: A real-world study

Risk Stratification System of Malignant Ovarian Germ Cell Tumors

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500096140
Enrollment
Unknown
Registered
2025-01-19
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant ovarian germ cell tumor

Interventions

Active surveillance group:active surveillance after fertility sparing surgery
Adjuvant chemotherapy group:adjuvant chemotherapy after fertility sparing surgery

Sponsors

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
1 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Pathologically confirmed ovarian malignant germ cell tumor; 2. 1-60 years old; 3. Life expectancy of more than 3 months; 4. Good compliance; 5. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Cannot be followed-up; 2. History of previous treatment of lung or liver disease; 3. Other malignant tumors in the past 5 years.

Design outcomes

Primary

MeasureTime frame
Alpha-fetoprotein, AFP;Neuron-specific enolases, NSE;Carbohydrate antigen 125;Carbohydrate antigen 199;Pelvic ultrasound;Hepatobiliary, pancreatic and splenic ultrasound;CT scan;Onlogical outcomes of patients between two groups;—

Secondary

MeasureTime frame
Anti-Müllerian hormone, AMH;Fertility outcomes of patients between two groups;Quality of life patients between two groups;—

Countries

China

Contacts

Public ContactJinhui Wang

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

yangjiaxin@pumch.cn+86 10 6915 2795

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026