postoperative cognitive dysfunction
Conditions
Interventions
Routine anesthesia management group:The anesthesiologist did not adjust the patients intraoperative medication plan according to the analyzer.
TCD Management Group:According to the data provided by the instrument, anesthesiologists will use vasoactive drugs, increase or decrease cyclophenol, speed up or slow down the infusion and other measu
Sponsors
the First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) 40<=age<=60 years old, no gender limit; ASA classification II~III; (2) 40kg/m^2<= BMI <=60kg/m^2; (3) For patients undergoing elective surgery under general anesthesia in our hospital, the expected operation time is 2-5 hours (including 2 and 5 hours); (4) Agree to participate in this trial and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those who are allergic to the active ingredients of anesthetics or all excipients; (2) Patients with positive preoperative delirium assessment method (CAM); (3) Inability to complete neuropsychological tests (including those with severe visual or hearing impairment); (4) Patients with serious risk of elevated blood pressure or intracranial pressure (such as pheochromocytoma, intracranial aneurysm, aortic dissection, etc.); (5) Cardiovascular history: uncontrolled hypertension [systolic blood pressure >= 170mmhg and / or diastolic blood pressure >= 105mmhg without antihypertensive drug treatment, or systolic blood pressure > 160mmhg and / or diastolic blood pressure > 100mmhg after antihypertensive drug treatment], aneurysm, severe arrhythmia, heart failure, Adams Stokes syndrome, New York Heart Association (NYHA) cardiac function classification >= III, severe superior vena cava obstruction syndrome, pericardial effusion, acute myocardial ischemia, unstable angina, myocardial infarction within nearly 6 months before screening, history of tachycardia / bradycardia requiring drug treatment, and degree II-III atrioventricular block;the; (6) History of respiratory system: severe chronic obstructive pulmonary disease, acute exacerbation of chronic obstructive pulmonary disease, severe airway stenosis, pharyngeal and laryngeal tumors, (bronchial) tracheoesophageal fistula or airway tear history, and severe respiratory tract infection within nearly 2 weeks before screening; (7) History of nervous and mental system: brain injury, convulsion, intracranial hypertension, cerebral aneurysm, cerebrovascular accident; Schizophrenia, mania, delirium, long-term use of psychotropic drugs, history of cognitive dysfunction, etc; (8) Combined with other important organ dysfunction: including severe liver and kidney dysfunction; Brain organic lesions, such as neoplastic vascular disease or arteriovenous malformation, stroke, dementia and other medical history; (9) Hospitalized due to disease within 3 months; (10) Have a history of alcohol, drug dependence or abuse; (11) Difficult follow-up or poor compliance; (12) The investigator believes that there are any other factors that are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of perioperative neurocognitive impairment in patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentrations of brain-derived neurotrophic factor, neuron specific enolase, and central nervous system specific protein in venous blood;The amount of vasoactive drugs used by patients during operation;Postoperative extubation time and PACU stay time of patients;Patients' hospitalization time, hospitalization expenses, satisfaction and complications; | — |
Countries
China
Contacts
Public ContactZhou Ting
The First Affiliated Hospital of Jinan University
Outcome results
None listed