Postoperative pain after upper limb surgery
Conditions
Interventions
Control group:Opioid intravenous analgesia
Experimental group:Add low-dose ketamine and dexmedetomidine to the postoperative analgesia pump
Sponsors
The Second Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 18 to 65 years old; 1.ASA Classification I-III; 2.Selective major surgery for unilateral upper limb fracture;
Exclusion criteria
Exclusion criteria: 1.Expected total surgical incision to be less than 5cm; 2.Preoperative presence of sick sinus syndrome, severe sinus bradycardia (heart rate<50 beats/minute), or second degree or higher atrioventricular block; 3.Presence of obstructive sleep apnea syndrome or body mass index above 28kg/?; 4.History of hyperthyroidism; 5.History of pheochromocytoma; 6.Severe liver and kidney dysfunction; 7.Recent history of drug abuse; 8.History of schizophrenia or epilepsy; 9.Allergies to the drugs involved in the plan; 10.Cognitive impairment or inability to communicate;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of severe pain within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of bolus;Adverse reactions;Sedative Level;Satisfaction with pain relief;Patient's subjective sleep quality; | — |
Countries
China
Contacts
Public ContactChaohui Lian
The Second Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed