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Effect of transcutaneous vagus nerve electrical stimulation on awakening of comatose patients after cerebral hemorrhage

Effect of transcutaneous vagus nerve electrical stimulation on awakening of comatose patients after cerebral hemorrhage

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500096114
Enrollment
Unknown
Registered
2025-01-17
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The patient found unconscious after a cerebral hemorrhage firstly

Interventions

Control group:Routine rehabilitation training
Experimental group:Routine rehabilitation training combined with transcutaneous vagal nerve stimulation

Sponsors

Yuebei People’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1.The patient who met the diagnostic criteria of hypertensive intracerebral hemorrhage were confirmed as intracerebral hemorrhage by head CT examination.Bedside data were not missing; No drugs affecting S100ß and NSE levels were taken before inclusion in the study; 2.Patients with coma after intracerebral hemorrhage and disturbance of consciousness form 28 days to 6 months; 3.No severe visual and somatosensory deficits before intracerebral hemorrhage; 4.Stable and could cooperate with electrophysiological tests; 5.18 to 85 years old.

Exclusion criteria

Exclusion criteria: 1.Patients with previous history of epilepsy, seizures, febrile convulsions and family history; 2.Intracranial implantation of metal, cardiac pacemaker and other electronic devices; 3.Combined with tumor, serious organ diseases with unstable vital signs; 4.Could not tolerate the test due to other reasons did not complete it; 5.Hemorrhage caused by tumors, ischemic stroke, etc; 6.Patients with severe hydrocephalus whose families refused surgery; 7.Stimulation severely damaged intolerance to stimulate the skin.

Design outcomes

Primary

MeasureTime frame
the FOUR scale;

Secondary

MeasureTime frame
Somatosensory evoked potential;the FIM scale of successful awakening patients;Proportion of patients successfully awakened;

Countries

China

Contacts

Public ContactHuihui Liu

Yuebei People’s Hospital

125210260@qq.com+86 751 691 3354

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026