Non-small cell lung cancer
Conditions
Interventions
non-third-generation (Non-3rd) EGFR-TKIs group:None
third-generation EGFR-TKIs treatment group:None
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of non-small cell lung cancer by histopathology; 2. Tumor tissue or body fluid samples tested negative for T790M by genetic testing; 3. First-line treatment with first- or second-generation EGFR-TKIs. 4. The patient has good compliance and can undergo regular follow-up visits; 5. The medical records are complete.
Exclusion criteria
Exclusion criteria: 1.Diagnosed with other malignancies within the last 5 years or a history of other malignancies, except for skin basal cell carcinoma, cervical carcinoma in situ, and breast ductal carcinoma in situ that have been effectively controlled; 2.Severe acute or chronic infections, including: Active infections requiring systemic treatment or systemic antibiotics; Known history of human immunodeficiency virus (HIV) infection and/or acquired immunodeficiency syndrome; patients with unknown HIV status who do not agree to undergo HIV testing are not eligible; Patients with active chronic hepatitis B or active hepatitis C infections, including those who test positive for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibody at screening. Patients cannot be enrolled until further quantitative testing clearly rules out the presence of active hepatitis B or C infection requiring treatment (e.g., HBV DNA <= 2500 copies/mL or 500 IU/mL, HCV RNA = lower limit of detection); 3.Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival;Second progression-free survival (PFS2); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactShujun Li
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed