Parkinson's disease
Conditions
Interventions
Experimental group:The rTMS of 10.0Hz was applied to the M1-DLPFC region of the dominant hemisphere of subjects in the true stimulation group with a stimulation intensity of 100% motor resting thresho
Control group:The coil is perpendicular to the surface of the skull, so it is an invalid stimulus, and the stimulation parameters, stimulation time, and stimulation frequency are the same as those of
Sponsors
Drum Tower Hospital, Affiliated Hospital of Medical School
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for Parkinson's disease in China (2016 edition); (2) Meet the diagnostic criteria for frozen gait; (3) If the subject is taking oral Parkinson's disease medication, he or she needs to have a stable drug regimen for at least 28 days, and the regimen should be kept unchanged during treatment and follow-up; (4) The age of the patient is between 40~75 years old; (5) Able to sign the informed consent form for the study.
Exclusion criteria
Exclusion criteria: 1.Pregnant woman; 2.Parkinson's syndrome (including traumatic, neoplastic, drug-induced, toxic, vascular and hydrocephalus, etc.) and Parkinson's syndrome; 3.With a history of epilepsy; 4.Patients with metal implants such as cardiac pacemakers and deep brain stimulation after treatment; 5.Patients with decompensated systemic disease; 6.CT or MRI showed calcification of striatum, lacunar infarction of striatum, hydrocephalus, and white matter abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The improvement of FOG;Improvement on exercise-related scales in Parkinson's disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of fMRI structural and functional brain networks; | — |
Countries
China
Contacts
Public ContactZhang Yang
Drum Tower Hospital, Affiliated Hospital of Medical School
Outcome results
None listed