polycystic ovary syndrome (PCOS)
Conditions
Interventions
chiglitazar:chiglitazar 48mg qd
metformin:metformin 1.5g qd
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: ? Age 18-40 years old; ?BMI of 24.0-38.0 kg/m^2; No other serious chronic diseases; Liver function, renal function, HIV/HCV and electrocardiogram were normal. The diagnostic criteria for polycystic ovary syndrome were met, and other diseases such as congenital adrenal hyperplasia, Cushing's syndrome and androgen secreting tumors were excluded. (Ref: Chinese expert consensus on total polycystic ovary syndrome, Chinese Journal of Endocrinology and Metabolism,2018,34(1) : 1-5); ? After fully understanding the content of the experiment, volunteer to be tested and sign the informed consent.
Exclusion criteria
Exclusion criteria: Diabetes mellitus (type 1 or type 2) was diagnosed before inclusion; ? Chronic heart, liver and kidney disease; Have drug allergy, allergic disease history or allergic constitution; Smokers and alcoholics; ? Combined with Cushing's syndrome, congenital adrenal hyperplasia, benign and malignant tumors of various systems, abnormal liver and kidney function, organic heart disease, rheumatoid arthritis, systemic lupus erythematosus, polycystic kidney, psychiatric diseases, HIV/ tuberculosis /HCV and other chronic diseases; ? History of using glucocorticoids, estrogens, progesterone and insulin within 3 months before inclusion; ? Patients who cannot cooperate with follow-up due to personal reasons; Also include: 1) patients who are participating in another clinical trial within one month before the trial; 2) Researchers consider other reasons not appropriate for clinical trial participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| testosterone;estradiol;Anti-mullerian hormone;Follicle-stimulating hormone;luteinizing hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glycosylated hemoglobin;triglyceride;cholesterol;low density lipoprotein cholesterin;high density lipoprotein cholesterol;weight;height; | — |
Countries
china
Contacts
Public ContactDongfang Liu
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed