Pain
Conditions
Interventions
Intervention group:Liposomal bupivacaine combined with hydrochloride bupivacaine for paravertebral block
Control group:hydrochloride bupivacaine for paravertebral block
Sponsors
Zhongshan Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients scheduled for elective two- or three-port thoracoscopic lung surgery; (2) No gender restriction, age = 18 years; (3) Requires endotracheal intubation for general anesthesia induction; (4) ASA Class I-III; (5) Voluntarily participates and signs informed consent.
Exclusion criteria
Exclusion criteria: (1) Allergic to any medications administered in the study; (2) History of severe liver dysfunction, i.e., Child-Pugh Class C; (3) Currently undergoing maintenance dialysis; (4) Congestive heart failure, i.e., New York Heart Association Class III or IV; (5) Untreated or unstable ischemic heart disease; (6) History of severe aortic or mitral valve disease; (7) History of multiple ventricular ectopic beats, multiple atrial ectopic beats, or atrial fibrillation; (8) Use of antidepressants or antipsychotic medications; (9) History of long-term use of analgesics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative 48-hour movement pain AUC (Area Under the Curve).; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative opioid consumption at PACU/24/48 hours postoperatively.;Postoperative 48-hour rest pain AUC (Area Under the Curve).;Postoperative QoR-15 score at 24h/48h ;Postoperative 24-hour / 48-hour sleep quality score.;Time of first rescue analgesic use and the amount used each time.;Adverse reactions, such as nausea, vomiting, dizziness, hypotension, etc.;Length of hospital stay;Anxiety score during hospitalization; | — |
Countries
China
Contacts
Public ContactLiang Chao
Zhongshan Hospital of Fudan University
Outcome results
None listed