Tuberculous meningitis
Conditions
Interventions
anti-tuberculosis treatment group:Patients were divided into three groups. This group is the standard anti-tuberculosis treatment group.
dexamethasone group:The patients were divided into three groups. The group was anti-tuberculosis + dexamethasone treatment group.
thalidomide group:The patients were divided into three groups. The group was anti-tuberculosis + thalidomide treatment group.
Sponsors
Department of Infectious Diseases, General Hospital of Xizang Military Command
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Participants must be aged between 18 and 65 years, regardless of gender; 2. Clinical symptoms and/or imaging (head MRI or CT) support the diagnosis of tuberculous meningitis; 3. No drug-resistance during initial tuberculosis treatment; 4. No previous treatment with hormones, immunosuppressants or biological agents; 5. Voluntarily sign the informed consent to participate in the project, and be able and willing to accept follow-up visits
Exclusion criteria
Exclusion criteria: 1. Participants with plans for pregnancy or currently pregnant, regardless of gender; 2. Lactating women; 3. Allergic to thalidomide; 4. Intolerant to thalidomide/first-line anti-tuberculosis drug therapy (isoniazid + rifampicin + ethambutol + pyrazinamide) or appearing severe drug reactions; 5. Participants with severe infections, autoimmune diseases, severe liver or kidney insufficiency, blood or tumor disorders; 6. Any other significant medical conditions, laboratory abnormalities or mental illnesses that the researcher considers inappropriate for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNFa;LTB4; | — |
Secondary
| Measure | Time frame |
|---|---|
| LTA4H mRNA;Modified Rankin Scale;Glasgow Coma Scale;TNFa mRNA; | — |
Countries
China
Contacts
Public ContactQianqi Wei
General Hospital of Xizang Military Command
Outcome results
None listed