Acute Pancreatitis
Conditions
Interventions
Grouping based on anti-inflammatory treatment methods:None
Sponsors
PLA Eastern Theater General Hospital (Jinling Hospital affiliated to Nanjing University Medical College)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 to 70 years old; 2.Meets the diagnostic criteria for AP (>= 2 items): Persistent upper abdominal pain, Serum amylase and/or lipase levels are three times higher than the upper limit of normal, Typical manifestations of abdominal imaging examination (pancreatic edema/necrosis or peripancreatic exudate); 3.Within 48 hours of AP onset; 4.When enrolled, CRP>150mg/L;
Exclusion criteria
Exclusion criteria: 1.Patients are expected to die within 48 hours after enrollment, defined as patients with norepinephrine usage at a dose of 25 mg/min or more under full-fluid resuscitation, with a systolic blood pressure <90mm Hg and serum pH values <7.0. The judgment will be made by the treating physician. 2.Failure to obtain informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of severe AP within 28 days after enrollment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systemic inflammatory response syndrome (SIRS) free days to 14 days after enrollment;Organ failure free days (OFFDs) to 14 days after enrollment;The incidence of new-onset organ failure within 14 days after enrollment; | — |
Countries
China
Contacts
Public ContactKe Lu
PLA Eastern Theater General Hospital (Jinling Hospital affiliated to Nanjing University Medical College)
Outcome results
None listed