goiter
Conditions
Interventions
experiment group:rhTSH 0.1mg/ml hip muscle im 24 hour before radioiodine treatment
Control group:1ml 0.9% saline hip muscle im 24 hour before radioiodine treatment
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the above diagnostic criteria; 2. Age >18 years old, male and female sex is not limited; 3. Thyroid volume 28ml-140ml(ultrasound), with or without benign nodules, and thyroid compression related symptoms or cosmetic needs, or both; 4. Normal TSH level or subclinical hyperthyroidism (i.e. serum TSH < 0.38 mU/L, serum T4 and T3 levels are normal); 5. Have contraindications for surgery or refuse surgery.
Exclusion criteria
Exclusion criteria: 1. Under 18 years of age; 2. Use of amiodarone or iodized contrast agents in the 12 months prior to enrollment; 3. Patients who do not want to participate in the study or do not want to sign informed consent; 4. Critically ill patients, suffering from mental diseases, can not cooperate with the examination of patients; 5. Pregnant and lactating women; 6. Severe heart diseases such as heart obstruction, heart failure, ventricular arrhythmia, and unstable angina pectoris within 3 months; 7. Severely impaired liver function (AST or ALT> 4 times the upper limit of normal); 8. Renal insufficiency (BUN or CR> 2 times the upper limit of normal); 9. The goiter has been treated with surgery or radioactive iodine; 10. Thyroid nodules indicate malignancy that cannot be confirmed by FNA cytology; 11. The volume of retrosternal goiter is 100 mL; 12. 24-hour thyroid absorption rate <20%.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thyroid volume reduction rate;Goiter related quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypothyroid; | — |
Countries
China
Contacts
Public ContactMa Chao
Shanghai the Tenth people's hospital
Outcome results
None listed