Postoperative nausea and vomiting
Conditions
Interventions
Research group:The respiratory parameters were adjusted during the operation to maintain PaCO2 45 ~ 55mmHg and pH > 7.2
Control group:By adjusting respiratory parameters during operation, PaCO2 was maintained at 35 ~ 45mmHg
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients who plan to undergo laparoscopic surgery in our hospital; 2. Age 18-65 years old; 3. body mass index (BMI) 18-28kg /m2; 4. American Society of Anesthesiologists (ASA) grades I to III; 5. Non-smokers; 6. Patients who did not take hormones, opioids or antiemetic drugs within 72 hours before surgery.
Exclusion criteria
Exclusion criteria: 1. The patient refused to sign the informed consent; 2. Patients intending to undergo gastrointestinal surgery; 3. Diabetic patients; 4. Patients with a history of motion sickness or PONV before surgery; 5. Those who have gastrointestinal diseases, craniocerebral diseases, otogenic diseases or who have received chemotherapy in the past few weeks; 6. Serious heart, lung, cerebrovascular diseases or liver and kidney function damage; 7. People with serious neurological or mental disorders; 8. Patients with elevated PaCO2 indicated by preoperative blood gas analysis; 9. Inability to understand or use visual analogue scale (VAS) scales and patient controlled intravenous analgesia (PCIA).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting;The severity of postoperative nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative adverse events;Wake-up time; | — |
Countries
China
Contacts
Public ContactMiao Zhuang
Dalian Medical University Affiliated First Hospital
Outcome results
None listed