none
Conditions
Interventions
experimental group:In the experimental group, anesthesia was induced by intravenous cis-atracurium 0.05mg/kg, remifentanil 4ug/kg using a micro pump, propofol and etomidate 1:1 mixture (induction dose
control group:Anesthesia induction in the control group was taken as conventional anesthesia induction with a 1:1 mixture of propofol and etomidate (induction dose 0.2 ml/kg), sufentanil 0.3-0.5ug/kg,
Sponsors
The People`s Hospital of Chongqing LiangPing District
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. age >= 65 years, gender is not limited; 2. patients undergoing elective laparoscopic cholecystectomy, appendectomy, ovariectomy, and herniotomy under general anesthesia; 3. ASA classification I-III; 4. 18kg/m^2 <= BMI <= 30 kg/m^2; 5. Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. those who have participated in clinical trials of other drugs within the last three months; 2. those who have taken monoamine oxidase inhibiting drugs or antidepressants within fifteen days; 3. patients with bronchial asthma, myasthenia gravis, peptic ulcer; 4. those who are allergic to or have contraindications to opioids, propofol, cis-atracurium, atropine, neostigmine and any components of excipients; 5. patients with a history of severe cardiovascular system diseases (e.g., patients with hypertension whose blood pressure is still grade 3 or higher even after treatment with antihypertensive drugs (i.e., resting systolic blood pressure >=180 mmHg and/or diastolic blood pressure >=110 mmHg), heart failure, and severe cardiac arrhythmia, etc.); patients with unstable angina pectoris or myocardial infarction in the last 6 months; resting electrocardiogram with heart rate <50 beats/minute, or third-degree atrioventricular conduction block ; 6. preoperative liver and renal function: alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN), creatinine (Cr) abnormalities (ALT and AST greater than 2 times the upper limit of normal, BUN and Cr greater than 1.5 times the upper limit of normal); 7. patients with craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, history of cerebrovascular accidents, and those suffering from diseases of the central nervous system and respiratory system (respiratory failure, etc.); psychiatric disorders (schizophrenia, mania, bipolar anomalies, delirium, etc.) and history of long-term use of psychotropic medication, and cognitive dysfunction; 8. patients who are unable to express their wishes correctly; those with poor compliance, unable to complete the trial according to the study protocol; 9. those who are considered by the investigator to be unsuitable for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tracheal extubation time;Sedation-agitation Scale(SAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Observer`s Assessment of Alertness/Sedation(OAAS);visual analogue scale(VAS);Blood pressure, mean arterial pressure, heart rate, BIS, respiration, oxygen saturation at different nodes of anesthesia induction maintenance;Incidence and grading of nausea and vomiting at different postoperative nodes; | — |
Countries
China
Contacts
Public ContactJinghua Wu
The People`s Hospital of Chongqing LiangPing District
Outcome results
None listed