hip fracture
Conditions
Interventions
NSAIDs group:Pain management will performed with NSAIDs as demanded after admission
Bupivacaine liposome group (LB group):PENGB was performed with liposome bupivacaine
Bupivacaine hydrochloride group(BP group):PENGB was performed with bupivacaine hydrochloride
Sponsors
Yangpu District Central Hospital(Yangpu Hospital, School of Medicine, Tongji University)
Eligibility
Sex/Gender
All
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients aged 65 years and above who will undergo internal fixation of hip fracture in in Yangpu District Central Hospital of Shanghai . a. American Society of Anesthesiologists(ASA) grade ?~?; b. New York Heart Association (NYHA) Heart Function grades ? to?; c. Relevant auxiliary test has been perfected, including blood routine, liver and kidney function, coagulation, electrocardiogram, ultrasound, blood gas analysis, etc.; d. NRS>3 at rest e. Volunteer to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: a. Patients with mental system disease or cognitive dysfunction; b. Patients with sensory disorders such as hyperalgesia, or other physical pain that affects the evaluation of pain; c. Patients with a history of myocardial infarction or unstable angina pectoris within six months, or severe arrhythmias (such as atrioventricular block of degree II and above); d. Patients with diabetic peripheral neuropathy; e. Persons known to be allergic to bupivacaine or other amide local anesthetics; f. Contraindications to subarachnoid block and PENGB g. Long-term use of analgesics h. drug or alcohol abuse i. Patients who had any other factors deemed unsuitable for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| pain scores;Hemodynamic parameters need to be dealt with in perioperative period;The occurrence of deep vein thrombosis;Total analgesic medication;Muscle strength of lower limb;Complications or special events (e.g., hematoma, nerve injury, local anesthetic poisoning, etc.) within 48 hours from surgery to surgery;Total length of stay (days);Total hospital expenses;In-hospital mortality and all-cause mortality at 3 months after surgery;Incidence of postoperative chronic pain;C-reactive protein;Serum amyloid A; | — |
Countries
China
Contacts
Public ContactYinglin Wang
Yangpu District Central Hospital(Yangpu Hospital, School of Medicine, Tongji University) ,
Outcome results
None listed