colorectal cancer
Conditions
Interventions
Placebo control group:In the placebo-controlled group, a single dose of 2 placebo capsules is administered. The placebo, provided by Beijing Hanmi Pharmaceutical Co., Ltd., is in the form of a capsule
Treatment group:In the treatment group, a single dose of 2 capsules of Bacillus subtilis and Enterococcus faecalis Enteric-Coated Capsules is administered. All patients receive a single dose (Bacillus
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age 35-65 years old; 2) Patients undergoing laparoscopic radical resection of colorectal cancer; 3) Patients voluntarily accept microecological therapy; 4) Operation duration is 2 to 6 hours; 5) The patient signed the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1) suffering from cognitive impairment (such as Alzheimer's disease, depression, bipolar disorder, etc.); 2) Have a history of abdominal surgery or allergic reaction to subtilis enteric-coated capsules; 3) The amount of blood lost during surgery exceeds 500mL; 4) Less than 3 months after participating in or completing other clinical trials; 5) Received broad-spectrum antibiotics within 3 months before surgery; 6) dysfunction of heart, liver and other vital organs; 7) Used probiotics within 3 months before surgery; 8) There are known causes of gastrointestinal dysfunction before surgery; 9) History of preoperative radiotherapy or chemotherapy; 10) History of preoperative use of anticoagulants and (or) antiplatelet drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative time to first flatus;Time of first feeding after surgery;the time of first formed stool after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| hospitalization duration;postoperative anastomotic leak incidence;incidence of intestinal obstruction; | — |
Countries
China
Contacts
Public ContactPengyuanWang
Peking University First Hospital
Outcome results
None listed