None
Conditions
Interventions
Group D:Dexmedetomidine infusion 0.3ug/kg/h during anaesthesia
Group E:Infusion of 0.3 mg/kg/h of esketamine during anaesthesia
Group C:Equivalent saline infusion during anaesthesia
Sponsors
Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 40-75 years old 2. ASA Grading II-III, NYHAI.-III, EF>=50% 3. Cardiac surgery under cardiopulmonary bypass (CPB) is planned
Exclusion criteria
Exclusion criteria: 1. Patients undergoing secondary cardiac surgery 2. Patients with intellectual disability, deafness, or mute or other conditions that affect normal communication 3. Previous neurological disease or psychiatric disease 4. History of sleep disorders requiring medical intervention (such as the use of sleeping pills) or PSOI score >=8 in the past month 5. Patients who are alcoholic, drug-addicted, and taking psychotropic drugs 6. Patients with obvious abnormal liver and kidney function affecting drug metabolism 7. Contraindications to the use of dexmedetomidine or esketamine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative sleep; | — |
Countries
China
Contacts
Public ContactShi Hongwei
Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University
Outcome results
None listed