Hyperuricemia (with or without gout)
Conditions
Interventions
Test group:ZC-URA ? composite lactic acid bacteria powder (specification: 2g/strip), diluted with water below 40 ? and consumed. 2 times a day, 1 piece each time, to be consumed after meals (breakfast
control group:ZC-URA ? Compound Lactic Acid Bacteria Powder Simulator (Specification: 2g/strip), diluted with water below 40 ? and consumed. 2 times a day, 1 piece each time, to be consumed after meal
Sponsors
Guangdong Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age range of 18-75 years old (including boundary values), gender not limited; 2. Blood uric acid level>450 µ mol/L on two non same day fasting periods of 5-6 hours (the first blood uric acid test can accept test results within 3 months); 3. The subjects are informed, voluntarily sign the informed consent form, and agree to participate in all visits, examinations, and treatments according to the requirements of the trial protocol.
Exclusion criteria
Exclusion criteria: 1. Secondary hyperuricemia caused by kidney disease, blood disease, or the use of certain trial foods, tumor radiotherapy and chemotherapy, organ transplantation, etc; 2. Patients with acute gout attacks or those with acute gout attacks within the past 2 weeks; 3. Merge patients with severe cardiovascular and cerebrovascular diseases, liver, kidney, hematopoietic system and other serious primary diseases, malignant tumors, and mental illnesses; Individuals with abnormal liver and kidney function (ALT, AST>1.5ULN; Scr>1.5ULN); 4. Patients with severe hypertension (systolic blood pressure >= 180mmHg and/or diastolic blood pressure >= 110mmHg); Type I diabetes or poorly controlled type II diabetes (fasting blood glucose >= 8.5 mmol/L); 5. Individuals with a body mass index (BMI) greater than 30kg/m^2; 6. Patients with previous intestinal diseases such as lactose intolerance, irritable bowel syndrome, inflammatory bowel disease, and habitual diarrhea; 7. Individuals with a history of taking antibiotics within the past week; Medications that affect uric acid metabolism or excretion and cannot be discontinued within one week, including azathioprine, 6-mercaptopurine, thiazide diuretics, aspirin (over 325mg/day), or other salicylates; 8. Those who require continuous prednisone treatment; 9. Pregnant and lactating women; 10. Allergic constitution or history of allergies to lactobacilli and their products; 11. Participated in other population intervention studies within 3 months prior to the screening period; 12. Other researchers believe that they are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum uric acid control compliance rate (= baseline level) after stopping trial feeding for 4 weeks; | — |
Countries
China
Contacts
Public ContactZheng Shaoling
Guangdong Second People's Hospital
Outcome results
None listed