Helicobacter pylori
Conditions
Interventions
Group A:Keverprazan Hydrochloride Tablets 10mg,bid+Amoxicillin 1000mg,tid
Group B:Keverprazan Hydrochloride Tablets 20mg,bid+Amoxicillin 1000mg,tid
Group C:Keverprazan Hydrochloride Tablets 20mg,bid+Amoxicillin 1000mg,bid+Furazolidone 100mg bid+Colloidal Bismuth Pectin 300mg bid
Sponsors
NanJing First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.(1) Ages 18-65; 2.(2) Patients who tested positive for H. pylori by 13C or 14C breath test and have not received previous eradication therapy; 3.(3) Voluntarily join the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.(1) Allergic to the study drug (e.g. penicillin allergy); 2.(2) Recent bleeding or within 4 weeks of bleeding history in the stomach or duodenum; 3.(3) Patients who have previously received eradication therapy for Helicobacter pylori; 4.(4) Use antibiotics or bismuth medication 4 weeks before starting the study;use P-CAB or PPI 2 weeks before starting the study; 5.(5) Patients who have had surgery on the stomach or intestines, which affects the drug's metabolism; 6.(6) Pregnant or lactating women; 7.(7) Patients with other serious physiological or psychological conditions, or those with liver or kidney dysfunction; 8.(8) Patients with Zollinger-Ellison syndrome, gastric mucosal-associated lymphoid tissue lymphoma (MALT), or malignant tumors; 9.(9) Patients with glucose-6-phosphate dehydrogenase (G-6PD) deficiency, peptic ulcer disease, or bronchial asthma; 10.(10) Patients with concomitant medications including azatanavir or lopinavir, tricyclic antidepressants, levodopa, paracetamol, codeine phosphate/dextromethorphan, monoamine oxidase inhibitors, tramadol, etc. 11.(11) Other factors that the investigator considers unsuitable for participation in the study, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficiency; | — |
Countries
China
Contacts
Public ContactZhangZhenyu
NanJing First Hospital
Outcome results
None listed