Pain
Conditions
Interventions
Ocelidine group (Group O):Ocelidine (0.03mg/kg) is injected when the pneumoperitoneum is stopped at the end of the operation, and the infusion is turned off when the last stitch is given to the surgeo
Sufentanil (Group S):Sufentanil (0.15ug/kg) is injected when the pneumoperitoneum is stopped at the end of the operation, and the infusion is turned off when the surgeon sutures the last stitch.
Placebo group (Group C):At the end of the operation, the same volume of normal saline is injected when the pneumoperitoneum is stopped, and the infusion is closed when the surgeon sutures the last sti
Sponsors
Nanchong Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.·Patients undergoing elective laparoscopic cholecystectomy under general anesthesia; 2.Age:18-65; 3.BMI:19-28kg/m^2; 4.ASA:I-II; 5.All candidates agreed to participate in the study and signed.
Exclusion criteria
Exclusion criteria: 1.Patients with acute heart failure, unstable angina pectoris, severe arrhythmia, poorly controlled hypertension and diabetes, etc; 2.Acute respiratory infections, AE COPD, poorly controlled asthma, etc; 3.ESRD,hepatic dysfunction; 4.Mental disorders include: schizophrenia, mania, bipolar disorder, etc; 5.Allergic to the Oliceridine; 6.Pregnant and lactant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain condition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative adverse events;Extubation choking reaction;Occurrence of agitation;Time to first postoperative rescue analgesia;Cumulative 24h postoperative rescue analgesic use; | — |
Countries
China
Contacts
Public ContactLi Linji
Nanchong Central Hospital
Outcome results
None listed