tooth stains
Conditions
Interventions
Control group:Control toothpaste for removing active ingredients
Test group:BIEMIN toothpaste
Sponsors
Hospital of Stomatology, Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Healthy adults (18 to 65 years old); 2. Willing to whiten their teeth; 3. Have 12 natural anterior teeth with extrinsic stains and no fillings or crown restorations; 4. Extrinsic stains refer to color changes and discoloration caused by lifestyle factors such as drinking tea, smoking, drinking red wine, and other dietary habits.) d) Have at least one tooth with dentin hypersensitivity, sensitive to tactile stimuli of 10g to 50g, and/or sensitive to cold air stimuli; 5. Signed informed consent and able to complete the clinical trial as required; 6. Not simultaneously participating in any other similar clinical trials; 7. Agree to postpone any non-emergency dental examinations, including professional cleaning, until the end of the trial; 8. Agree not to use any non-study toothpaste or mouthwash during the trial period; 9. Have not used the following medications in the month prior to the study: anticonvulsants, antihistamines, antidepressants, sedatives, and tranquilizers.
Exclusion criteria
Exclusion criteria: 1. Simultaneously participating in other clinical studies; 2. Women who are pregnant or breastfeeding; 3. History of allergy to the product or its components; 4. Suffering from AIDS, insulin-dependent diabetes, undergoing anticancer chemotherapy within the last 6 months, immunodeficiency, autoimmune diseases, or other serious illnesses; 5. Suffering from uncontrolled gingivitis, periodontal disease, or oral ulcers, or wearing partial or full dentures; 6. Smoking or using tobacco products; 7. Any condition or disease that, in the opinion of the investigator, may affect the subject's safe completion of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lobene stain index, LSI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity; | — |
Countries
China
Contacts
Public ContactDu Mi
Hospital of Stomatology, Shandong University
Outcome results
None listed