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Characterization of intestinal flora-metabolites in dyslipidemic patients and their association with lipid metabolism and immune functions

Characterization of intestinal flora-metabolites in dyslipidemic patients and their association with lipid metabolism and immune functions

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096000
Enrollment
Unknown
Registered
2025-01-16
Start date
2025-02-15
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dyslipidemia

Interventions

Dyslipidemia group:NA
Healthy person control group:NA

Sponsors

School of Public Health, Southeast University/ Zhongda Hospital, Southeast University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria for the case group were: (1) men or women aged 18 to 65 years; (2) permanent residents of the region; (3) lipid levels in accordance with any one of the diagnostic criteria in the 2016 Chinese Guidelines for the Prevention and Control of Dyslipidemia in Adults, i.e., serum TC greater than or equal to 5.2 mmol/L, serum TG greater than or equal to 1.7 mmol/L, serum HDL-C less than or equal to 1.0 mmol/L, and serum LDL-C greater than or equal to 3.4 mmol/L. Serum TC is greater than or equal to 5.2 mmol/L, serum TG is greater than or equal to 1.7 mmol/L, serum HDL-C is less than or equal to 1.0 mmol/L, serum LDL-C is greater than or equal to 3.4 mmol/L. (4) No related diseases such as hepatic, renal, cerebral, cardiovascular, and type 1 or type 2 diabetes mellitus. (5) Cases were newly diagnosed within one month and were not taking relevant lipid-modifying drugs. (6) Signed informed consent and participated in the study voluntarily. Inclusion criteria for the control group: (1) male or female aged 18 to 65 with BMI of 18.5-23.9 kg/m^2; (2) permanent residents of the region; (3) lipid levels within the range of normal healthy people; (4) no serious liver, kidney, gastrointestinal, endocrine diseases and complications related to chronic diseases; (5) signing an informed consent form and voluntarily participating in the survey.

Exclusion criteria

Exclusion criteria: The exclusion criteria for the case group were: (1) non-resident in the region; (2) women in special periods, such as pregnancy, lactation, or special dietary habits, such as ketogenic diet, diet, vegetarian; (3) frequent travelers outside the unit. Exclusion criteria for the control group: (1) non-resident in the region; (2) frequent business travelers outside the unit.

Design outcomes

Primary

MeasureTime frame
TG, TC, LDL-C, HDL-C;routine blood test;Peripheral blood lymphocyte subset CD48+;

Secondary

MeasureTime frame
intestinal flora;

Countries

China

Contacts

Public ContactSun Guiju

School of Public Health, Southeast University

gjsun@seu.edu.cn+86 139 5192 8860

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026