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The effect of esketamine on postoperative recovery in patients with preoperative depression

The effect of esketamine on postoperative recovery in patients with preoperative depression: a randomized, double-blind controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500095983
Enrollment
Unknown
Registered
2025-01-15
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Concrol group:None
Experimental group:Preoperative administration of 0.2mg/kg esketamine by pump for 40 minutes

Sponsors

Xuanwu Hospital Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.18 7 points; 7. Have a clear understanding and voluntarily participate in the study, and sign the informed consent form by themselves.

Exclusion criteria

Exclusion criteria: 1. In addition to general venous anesthesia, other anesthesia methods are required, such as epidural and subarachnoid anesthesia; 2. Other types of surgeries other than those specified in the enrollment criteria; 3. Patients with severe abnormal liver and kidney function; 4. Refusal to use analgesic pump patients; 5. Presence of contraindications or caution to the use of esketamine.

Design outcomes

Primary

MeasureTime frame
Recovery quality score on the first postoperative day;

Secondary

MeasureTime frame
The quality of recovery scores of the two groups on the third day after surgery and before discharge were performed;Comparison of depression tendency index between the two groups on the first and third days after surgery and before discharge;Comparison of analgesia between the two groups after surgery;Comparison of postoperative gastrointestinal function recovery between two groups;Adverse reaction incidence rate;Incidence of postoperative complications in two groups;

Countries

China

Contacts

Public ContactWang Tianlong

Xuanwu Hospital Capital Medical University

w_tl5595@hotmail.com+86 10 83199333

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026