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Exploration of Efficacy Differences and Influencing Factors of Immunotherapy for Non-Small Cell Lung Cancer in High-Altitude and Low-Altitude Regions Based on Multimodal Data Integration Analysis

Exploration of Efficacy Differences and Influencing Factors of Immunotherapy for Non-Small Cell Lung Cancer in High-Altitude and Low-Altitude Regions Based on Multimodal Data Integration Analysis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500095980
Enrollment
Unknown
Registered
2025-01-15
Start date
2025-04-01
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-Small Cell Lung Cancer (NSCLC)

Interventions

High Altitude Group:NA
Low Altitude Group:NA

Sponsors

Xi'an Jiaotong University Second Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or older, regardless of gender. 2. Diagnosed with primary non-small cell lung cancer (NSCLC) confirmed by clear cytological or histopathological evidence. 3. Receiving antitumor immunotherapy for the first time. 4. At least one efficacy evaluation during the treatment period. 5. Voluntarily participating in the study with a strong willingness to cooperate.

Exclusion criteria

Exclusion criteria: 1. Unknown histopathological type. 2. Missing records of antitumor treatment information, or participation in blinded drug clinical trials resulting in unclear medication details. 3. Concurrent malignant tumors that have not been radically resected. 4. Previous treatment with immunotherapies other than immune checkpoint inhibitors. 5. Patients unwilling to participate in the study or with a poor willingness to cooperate.

Design outcomes

Primary

MeasureTime frame
Progression-Free Survival (PFS);

Secondary

MeasureTime frame
Event-Free Survival (EFS);Overall Survival (OS);Disease-Free Survival (DFS);Pathological Complete Response (PCR);Objective Response Rate (ORR);Metastasis;Immune-Related Adverse Events (irAEs);Treatment-Related Adverse Events (TRAE);Serious Adverse Event (SAE);Major Pathological Response (MPR);

Countries

China

Contacts

Public ContactGuo hui

Xi'an Jiaotong University Second Affiliated Hospital

guohuihappy97@163.com+86 13572824106

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026