Stroke
Conditions
Interventions
Normal control group:Routine rehabilitation training
sham rTMS combined with BCI group:On the basis of routine rehabilitation training, patients were given BCI rehabilitation training after sham rTMS intervention
low frequency rTMS combined with BCI group:On the basis of routine rehabilitation training, patients were given BCI rehabilitation training after low-frequency rTMS (1Hz) treatment intervention.
High-frequency rTMS combined with BCI group:On the basis of routine rehabilitation training, the patients received high-frequency rTMS (10Hz) treatment intervention and then received BCI rehabilitatio
BCI brain control mode of TMS group:On the basis of routine rehabilitation training, the patients underwent 30 minutes of BCI brain-controlled magnetic stimulation training.
BCI brain control mode of sham TMS group:On the basis of routine rehabilitation training, patients underwent 30 minutes of BCI brain-controlled sham magnetic stimulation stimulation.
Sponsors
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Normal control group: Select age and gender matched normal individuals as the control group. 2. Patients’ group: (1) Meet the diagnostic criteria for stroke (cerebral hemorrhage and cerebral infarction) formulated by the fourth National Conference on Cerebrovascular Diseases; (2) Head CT and magnetic resonance examination confirmed the first onset, accompanied by complete upper limb motor dysfunction, the manifestations of NIHSS>7, SAFE0.15; (3) MRI and intracranial vascular examination confirmed that the focal site of stroke was the middle cerebral artery blood supply area; (4) Patients included in this study agreed to sign informed consent forms and related documents.
Exclusion criteria
Exclusion criteria: 1 Patients with limb dysfunction caused by other neurological diseases; 2 The lesion sites were non-middle cerebral artery blood supply areas such as brainstem and cerebellum; 3 There are serious cognitive disorders (MMSE<16 points), speech disorders, mental disorders and consciousness disorders, such as inability to cooperate; 4 Taking drugs that have an effect on cortical excitability or muscle activity (mainly including tricyclic antidepressants, benzodiazepines, muscle relaxants, nerve blockers and antiepileptic drugs); 5 Patients with progressive stroke or malignant progressive hypertension, serious visceral system diseases, etc.; 6 Patients with severe shoulder pain, shoulder-hand syndrome or shoulder dislocation; 7 Patients with contraindications to rTMS therapy such as epilepsy and metal implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Upper limb motor function index;Metabolomics indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroelectrophysiological index;Neuroimaging index;Near-infrared brain function imaging index;EEG index; | — |
Countries
China
Contacts
Public ContactGong Yan
Suzhou Municipal Hospital
Outcome results
None listed