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Development and validation of a risk prediction model for citrate accumulation in patients undergoing continuous renal replacement therapy with regional citrate anticoagulation

The Analysis of Risk Factors and Development of a Predictive Model for Citrate Accumulation in Patients Undergoing Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500095960
Enrollment
Unknown
Registered
2025-01-15
Start date
2023-08-09
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney disease

Interventions

Modeling group:none
Validation group:none

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Patients who underwent continuous renal replacement therapy with topical citrate anticoagulation in West China Hospital of Sichuan University from May 2021 to May 2023; (2) Age>=18 years; (3) Duration of CRRT treatment>=24h; (4) There is complete clinical case information.

Exclusion criteria

Exclusion criteria: (1) tCa/iCa ratio was not measured; (2) alteration of anticoagulation strategy due to reasons other than citrate accumulation; (3) received other types of blood purification therapy, such as plasma exchange (PE) or dual filtration plasmapheresis (DFPP), during CRRT; (4) Have participated in another study.

Design outcomes

Primary

MeasureTime frame
Total calcium;PH;Anion gap;Ion-calcium;Base excess;—

Countries

China

Contacts

Public ContactYi Zheng

Department of Nephrology, West China Hospital, Sichuan University

2013104981@qq.com+86 158 8246 5086

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026