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To determine the 50% effective dose of cyclopol for inhibiting endotracheal intubation response

To determine the 50% effective dose of cyclopol for inhibiting endotracheal intubation response

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500095959
Enrollment
Unknown
Registered
2025-01-15
Start date
2024-11-02
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gynecologic surgery patients

Interventions

intervention group:The cyclopol dose for the first patient was set at 0.4 mg/kg, and the cyclopol dose for the next patient was determined based on the presence or absence of intubation reactions

Sponsors

Nanchong City Central Hospital, Second Clinical Medical College, North Sichuan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective general anesthesia, regardless of gender, aged 18-65 years; 2. BMI 19-28kg/m^2; 3. ASA ?-?; 4. All participants agreed to participate in the study and signed

Exclusion criteria

Exclusion criteria: (1) Acute heart failure, unstable angina pectoris, myocardial infarction occurred within 6 months; (2) The basic values measured in the room: systolic blood pressure>160mmHg or diastolic blood pressure>100mmHg, heart rate 100bpm; (3) acute respiratory tract infection, COPD acute attack, poor control of asthma; (4) end-stage renal failure and liver decompensation; (5) Mental disorders such as schizophrenia, depression and cognitive dysfunction, etc.; (5) Allergic to the study drug; (7) All landowners nearly three months have a history of benzodiazepine medication; (8) End of pregnant women and lactating women; (9) Pet-name ruby is expected in patients with difficult airway.

Design outcomes

Primary

MeasureTime frame
intubation response;Number of adverse reactions;

Secondary

MeasureTime frame
General indicators of patients before operation;Intraoperative hemodynamic data;Time to intubation;

Countries

China

Contacts

Public ContactLinji Li

Nanchong City Central Hospital, Second Clinical Medical College, North Sichuan Medical College

llj-stephen@163.com+86 155 8300 9555

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026