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A Study on Evaluating the Efficacy of Low-Frequency rTMS Combined with Motor Imagery Therapy for Post-Stroke Lower Limb Motor Impairment Using Diffusion Tensor Imaging (DTI) Technology

A Study on Evaluating the Efficacy of Low-Frequency rTMS Combined with Motor Imagery Therapy for Post-Stroke Lower Limb Motor Impairment Using Diffusion Tensor Imaging (DTI) Technology

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500095930
Enrollment
Unknown
Registered
2025-01-15
Start date
2021-09-07
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Infarction

Interventions

rTMS group:The rTMS group received rTMS treatment in addition to conventional physical rehabilitation therapy.Each treatment session lasted 20 minutes, once daily, five times a week, for a duration of
Motor Imagery group:The MI group received MI training in addition to conventional physical rehabilitation therapy, with each session lasting 15 minutes conducted once a day, five times a week, for thr
rTMS+Motor Imagery group: in addition to conventional physical rehabilitation therapy, rTMS intervention was conducted, followed by continued treatment with MI training after rTMS session. Once daily,

Sponsors

Jinhua Hospital of TCM Affiliated to Zhejiang University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Diagnosed as stroke according to the World Health Organization's definition of stroke and further confirmed by head CT or MRI scan; (2) Diagnosis of cerebral infarction by cranial CT or MRI; (3) the first onset of the disease; (4) The course of the disease is within 3 months; (5) Be between the ages of 30 and 65; (6) Stable vital signs; (7) There was hemiplegic motor dysfunction, and the initial score of Fugl-Meyer Lower Extremity Motor Function Rating Scale (FMA-LE) was between 11 and 21 points; (8) Be conscious, have intact basic cognitive function, have the willingness to participate, and have signed the informed consent form before the start of the study.

Exclusion criteria

Exclusion criteria: (1) Unstable vital signs or severe organ dysfunction; (2) Severe cognitive impairment, unable to cooperate with the completion of training; (3) motor dysfunction of the lower limbs caused by other neurological diseases; (4) Have a history of seizures; (5) Intracranial metal implants, pacemakers or stent implants; (6) There are other factors that affect MRI data acquisition, such as motion artifacts.

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer Lower Extremity Motor Function Scale(FMA-LE);

Secondary

MeasureTime frame
Holden Walking Function Classification(FAC);"Timed Up and Go" Test(TUGT);Fractional Anisotropy(FA);Relative Fractional Anisotropy (rFA);

Countries

China

Contacts

Public ContactJiasheng Wang

Jinhua Hospital of TCM Affiliated to Zhejiang University of Traditional Chinese Medicine

JiashengWang1020@126.com+86 151 6796 3065

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026