childhood systemic lupus erythematosus
Conditions
Interventions
Observation group :Standard treatment combined with biological targeted therapy
control group:Standard treatmen
Sponsors
The Affiliated Xuzhou Children's Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Meet the 2019 EULAR/ACR classification criteria for SLE; 2. Combined with kidney injury, the diagnostic criteria for LN are based on the clinical evaluation, renal pathological test results and laboratory test results of SLE. 3. Children who completed 24 weeks and above follow-up.
Exclusion criteria
Exclusion criteria: 1. Kidney damage caused by other diseases, such as: TMA; 2. The efficacy is not evaluable or the efficacy is unknown; 3. Children with < 24 weeks lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complement c3 and c4;Immunoglobulins ( IgG, IgA, IgM ) and cellular immunity ( CD4, CD8, CD19 );Anti-double-stranded DNA titer;24 h urinary protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| SLEDAI-2000 score;Recurrence rate and remission rate;Glucocorticoid and immunosuppressant involvement;Organ involvement index after recurrence; | — |
Countries
China
Contacts
Public ContactPeng Qianqian
The Affiliated Xuzhou Children's Hospital of Xuzhou Medical University
Outcome results
None listed