Postop rative Delirium, POD
Conditions
Interventions
Lidocaine group:Before induction, administer a loading dose of lidocaine at 1.5 mg/kg within 15 minutes, and during the maintenance phase, administer a continuous intravenous infusion at a rate of 1.5
Control group:
Before induction, administer a volume-equivalent saline solution as a loading dose within 15 minutes in the lidocaine group, and during the maintenance phase, administer an equal volume
Sponsors
The Second Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: (1) American Society of Anesthesiologists (ASA) Physical Status Classification: Grade I-III; (2) Age between 65 and 90 years; (3) Elderly patients scheduled for elective major spinal surgery. To minimize the influence of risk factors for delirium, such as the type and duration of surgery, "major spinal surgery" here specifically refers to posterior lumbar interbody fusion (PLIF) involving >2 levels of instrumented fusion. This standardizes the level of surgical trauma and postoperative analgesic requirements.
Exclusion criteria
Exclusion criteria: Exclusion Criteria: Exclusion criteria: (1) preoperative mental disorder, cognitive dysfunction or communication difficulties; (2) obvious sinus bradycardia (heart rate <50 beats/min) or other serious cardiovascular diseases; (3) symptomatic cerebrovascular disease (such as previous stroke); (4) History of liver and kidney dysfunction (lidocaine allergy).
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Assessment of Acute Postoperative Pain;Severity of delirium;Onset and duration of delirium.; Incidence of agitation during the awakening period;Incidence of intraoperative and postoperative adverse events.;Intraoperative opioid consumption dose, total opioid dose during and after surgery;Intraoperative opioid consumption dose, total opioid dose during and after surgery.; | — |
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium in the first seven days postoperative.; | — |
Countries
China
Contacts
Public ContactDajiang Yuan/Jindi Jia
The Second Hospital of Shanxi Medical University
Outcome results
None listed