Non motor symptoms including depression and cognitive impairment in Parkinson' s disease
Conditions
Interventions
Real-iTBS group:intermittent theta-burst stimulation (iTBS)
Sponsors
Xi'an Jiaotong University Second Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Patients with Parkinson's disease (PD) who have been diagnosed according to the PD diagnostic criteria established by MDS in 2018, with Hoehn and Yahr (H-Y) stage 2-4 and aged 18-85 years; 2.Have good cooperation and demonstrate a certain level of compliance; 3.With normal vision, hearing, and language comprehension and expression abilities; 4.PD patients included in the experiment are receiving standard anti-Parkinson's medication treatment; 5.Commit to adhering to the research procedures, cooperating throughout the entire research process, and are willing to sign the informed consent form for the study.
Exclusion criteria
Exclusion criteria: 1.Patients with severe cognitive or emotional disorders that prevent them from completing the experiment; 2.Patients with other organic lesions in the central nervous system, such as cerebrovascular diseases, encephalitis, tumors, or a history of severe epilepsy; 3.Patients with other diseases that affect cognitive function, such as Parkinsonism; 4.Patients with a history of other mental illnesses or a family history of mental illnesses, such as schizophrenia, bipolar disorder, or autism; 5.Patients with metal objects in the head, such as cerebrovascular stents, cochlear implants, or other metallic implants; 6.Patients with cardiac pacemakers, heart stents, etc; 7.Patients with severe visual or hearing impairments; 8.Patients who are currently participating in another clinical trial; 9.Patients for whom the researcher deems there may be any conditions that could harm the subject or render them unable to meet or perform the requirements of the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale-17 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Montreal Cognitive Assessment score;The number of words during Verbal Fluency Task;Boston Naming Test score;Animal Verbal Fluency Test score;Parameters of Oxyhemoglobin;Functional Connectivity;The shortest path length;Clustering coefficient;Small-Worldness s;modularity statistic;Global Efficiency;Local Efficiency;Trail Making Test-A/B score;Clock Drawing Test score;Parkinson’s Disease Questionnaire-39 score;Latency of Event-Related Potentials P300;Hamilton Anxiety Scale score;Auditory Verbal Learning Test score; | — |
Countries
China
Contacts
Public Contactlibo li
Xi'an Jiaotong University Second Affiliated Hospital
Outcome results
None listed