postoperative delirium
Conditions
Interventions
Insulin intranasal administration group:40U insulin was administered nasally
Dexmedetomidine intranasal administration group:1.5ug/kg dexmedetomidine was administered nasally
Insulin combined with dexmedetomidine intranasal administration group:0U insulin combined with 1.5ug/kg dexmedetomidine was administered nasal
Sponsors
Yichang Central People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1) Age 65-95 years, no gender; 2) ASA classification: Grade I-; 3) BMI18-28 kg/m^2; 4) preoperative diagnosis of hip fracture or femoral neck fracture; 5) independent behavior, conscious and able to complete the test.
Exclusion criteria
Exclusion criteria: 1) Patients with contraindicated nasal administration (e. g., damaged or lesions); 2) patients with history of insulin and dexmedetomidine allergy; 3) history of cerebrovascular accident with sequelae; 4) patients with Alzheimer's disease or Parkinson's disease; 5) patients with severe liver and kidney disease; 6) patients who refused the protocol or lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CAM-ICU Assessment Scale;PSQI; | — |
Countries
China
Contacts
Public ContactAihua Shu; Yuxia Jiang
Yichang Central People's Hospital
Outcome results
None listed