Depression with suicidal ideation
Conditions
Interventions
control group:selective serotonin reuptake inhibitor,SSRI
Observation group:Intravenous infusion of esketamine
Sponsors
Huzhou Third Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.ASA I~II level patients; 2.Patients aged 18-65, gender not limited; 3.Patients with HAMD17 score >=17; 4.Patients rated as high risk or very high risk by C-SSRS.
Exclusion criteria
Exclusion criteria: 1.Patients allergic to any component of esketamine; 2.Patients with a serious risk of hypertension or increased intracranial pressure, and with uncontrolled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure exceeding 180/100mmHg); 3.Pregnant or breastfeeding women; 4.Patients with severe diseases of important organs such as heart, brain, liver, and kidney; 5.Obese patients or with severe snoring; 6.Patients with hyperthyroidism; 7.Patients with other serious mental illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Rating Scale for Depression, HAMD-17;Columbia-Suicide Severity Rating Scale,C-SSRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Frontal lobe oxygenated hemoglobin concentration in near-infrared brain imaging; | — |
Countries
China
Contacts
Public ContactJuanjuan Huang
Huzhou Third Municipal Hospital
Outcome results
None listed