Postoperative pain
Conditions
Interventions
Control group (N group) :Analgesic pump to be sufentanil 2.0µg/kg + metoclopramide 20mg + saline diluted to 100ml, analgesic pump background infusion rate of 2ml/h, self-control of a single dose of in
Intervention group1 (s1 group) :The analgesic pump was given esketamine 0.25mg/kg + sufentanil 1.5µg/kg + metoclopramide 20mg + saline diluted to 100ml.
Intervention group2 (s2 group) :The analgesic pump was given esketamine 0.5mg/kg + sufentanil 1.5µg/kg + metoclopramide 20mg + saline diluted to 100ml.
Intervention group3 (s3 group) :The analgesic pump was given esketamine 1.0mg/kg + sufentanil 1.5µg/kg + metoclopramide 20mg + saline diluted to 100ml.
Sponsors
The Second People’s Hospital of Hefei
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) The patient is to undergo lumbar decompression fusion and internal fixation, ASA grade I-II; (2) Patient's age>=40 years, <=65 years; (3) Body Mass Index (BMI) 19~24 kg/m^2; (4) The patient's communication is normal and has a certain learning ability.
Exclusion criteria
Exclusion criteria: (1) Severe respiratory and circulatory diseases: such as severe coronary atherosclerosis, acute myocardial infarction, respiratory failure and other underlying diseases; (2) Nervous system diseases: such as severe cerebral hemorrhage or sequelae of cerebral infarction, hemiplegia, aphasia, etc.; (3) Mental and psychological diseases: such as schizophrenia, depression, etc.; (4) Long-term abuse of analgesics, history of chronic pain, etc.; (5) Combined with obvious abnormal liver and kidney function; (6) Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale, VAS;Ramsay Sedation Scale;Dosage of sufentanil used;The end time of the operation;Heart Rate;SPO2;Mean Arterial Pressure, MAP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Awakening restlessness;Postoperative Nausea and Vomiting ,PONV;Hypotension;Adverse reactions;Quality of Recovery-15" scale, QoR-15; | — |
Countries
China
Contacts
Public ContactJunjie Liu
The Second People’s Hospital of Hefei
Outcome results
None listed