Knee joint disease
Conditions
Interventions
Esmketamine group(part ?):Induction of anaesthesia: propofol 1.5 mg/kg, esketamine 1x ED95 mg/kg
Remifentanil group(part ?):Induction of anaesthesia: propofol 1.5mg/kg, remifentanil 1ug/kg
Esmketamine combined with small dose of propofol (1.5mg/kg) was the 50% effective dose for successful LMA insertion group(part ?):Induction of anaesthesia: propofol 1.5mg/kg, 2 minutes later intraveno
Sponsors
Tianjin Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.age 18-65 years old; 2.BMI18~30kg/m2; 3..American Society of Anesthesiologists (ASA) classification I to? ;4.Patients with knee arthroscopic meniscus cleaning or knee arthroscopic free body removal;
Exclusion criteria
Exclusion criteria: 1. severe cardiovascular disease;2. severe respiratory disease;3.recent history of analgesic and sedative use; 4. history of psychiatric disorders; 5.allergy to ketamine or contraindication to its use; 6. cervical spine limitation of movement; 7. the opening is less than two fingers to anticipate the difficulty of laryngeal mask placement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea and vomiting;Successful placement of the laryngeal mask; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs at different times (mean arterial pressure, heart rate); | — |
Countries
China
Contacts
Public ContactLi Hongwei
Tianjin Hospital
Outcome results
None listed