sialorrhea after True Bulbar Palsy
Conditions
Interventions
Experimental group:30IU botulinum toxin per submandibular gland and 20IU botulinum toxin per parotid gland on both sides
Control group:Inject equal doses of placebo (physiological saline)
Sponsors
Fuxing Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18-80 years old; 2. Head MRI or CT confirms the presence of medullary lesions (bleeding, ischemia, and tumors); 3. After conducting a flexible endoscopic evaluation of swallowing (FEES), it was confirmed that there were swallowing disorders; 4. Accompanied by salivation, if the total score of the drooling severity and frequency scale (DSFS-T) is >= 4 points, or if each item of the drooling severity and frequency scale (DSFS) scores >= 2 points, or if the Murray secretion scale (MSS) score of the throat is >= 2 points, meeting any one of the above three criteria is considered to have salivation; 5. Clear consciousness, able to cooperate with drooling assessment and follow-up; 6. Agree to receive BTX-A injection, provide informed consent for this study, and sign relevant documents;
Exclusion criteria
Exclusion criteria: 1. having received BTX-A injection therapy in the past six months; 2. Allergic or contraindicated to botulinum toxin; 3. Have taken medication for the treatment of drooling or medication that can cause drooling in the past month; 4. Serious heart, lung, liver, kidney and other important organ diseases or malignant tumors; 5. Simultaneously using aminoglycoside antibiotics and warfarin: 6. Patients with infection or skin lesions at the injection site, or severe muscle atrophy or infection at the injection site, as well as those with infection or skin lesions at the injection site, or severe muscle atrophy or infection at the injection site.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global Impression of Change Scale;Murray secretion scale MSS;Hamilton depression scale,HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| DSFS-S andDSFS-F;pneumonia; | — |
Countries
China
Contacts
Public ContactHou Yajing
Fuxing Hospital affiliated to Capital Medical University
Outcome results
None listed