Pain within 48 hours after orthopedic trauma surgery
Conditions
Interventions
Oxelidine combined with flurbiprofen and dexmedetomidine:0.4mg/ kg Oxelidine ?4mg/ kg flurbiprofen and dexmedetomidine2 µg/ kg plus normal saline,total 100ml
Sufentanil combined with flurbiprofen and dexmedetomidine:2µg/ kg sufentanil ?4mg/ kg flurbiprofen and dexmedetomidine2 µg/ kg plus normal saline,total 100ml
Sponsors
Shaanxi 215 Hospital of nuclear industry
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria: 18-60 years old; 2.BMI: 18.5-30kg/m2; 3.ASA grades I-II; 4.patients requiring postoperative analgesic pump therapy and elective trauma orthopedics surgery;
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria: patients with severe heart, brain, lung, liver, and kidney diseases; 2.long-term use of opioids and sedative drugs, allergic to drug-related ingredients; 3.postoperative transfer to ICU patients;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Pain Scale (VAS) at 6, 12, 24, and 48 h postoperatively.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of uses of PCA;Changes in inflammatory markers within 24 hours after surgery;Patient satisfaction;Incidence of nausea and vomiting;First anal exhaust time;Urethral extraction time;postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactLiuqin Jiang
Shaanxi 215 Hospital of nuclear industry
Outcome results
None listed