non-criteria obstetric antiphospholipid syndrome
Conditions
Interventions
Group of non-standard antiphospholipid syndrome and preeclampsia:None
Control group:None
Sponsors
Shijiazhuang Fourth Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) Pre eclampsia meets the diagnostic criteria of the 9th edition of the Obstetrics and Gynecology textbook, while patients with non-standard obstetric antiphospholipid syndrome meet the definition of NCOAPS in the "Expert Consensus on Diagnosis and Management of Obstetric antiphospholipid Syndrome". They only meet the clinical or laboratory criteria in the APS classification criteria, including: clinical manifestations that meet the APS criteria, atypical laboratory tests (2 aPL positive but with a detection interval of less than 12 weeks), IgG/IgM type anticardiolipid (aCL), and/or he titer of anti - ß 2-GPI antibody is 20-39GPL/MPL or 95-99th percentile); Or laboratory tests meet APS criteria, with atypical clinical manifestations (2 consecutive unexplained abortions; or 3 or more non consecutive unexplained abortions; or late-onset preeclampsia; or placental hematoma, placental abruption, late preterm birth). (2) Complete clinical data. (3) Anticardiolipin antibodies (ACA), lupus anticoagulant, anti - ß 2 glycoprotein I antibodies, and D2 oligomers were detected between 12-16 weeks of pregnancy and before delivery.
Exclusion criteria
Exclusion criteria: (1) Multiple pregnancies; (2) Fetal chromosomal abnormalities and structural abnormalities; (3) Pregnancy loss caused by infection, metabolic factors, endocrine factors, chromosomal abnormalities, anatomical abnormalities, and other reasons; (4) Merge other systemic autoimmune diseases; (5) Combining hereditary thrombophilia or nephrotic syndrome, malignant tumors, and other acquired thrombophilia; (6) Merge hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anticardiolipin antibody;Anti - ß 2 glycoprotein 1 antibody;lupus anticoagulant;blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| platelet;family history;History of hypertension in the past;body mass index;age;Maternity history;urinary protein;D-Dimer; | — |
Countries
China
Contacts
Public ContactMeng Yancen
Shijiazhuang Fourth Hospital
Outcome results
None listed