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The genetic mutation in high hyperopia and microphthalmia

The genetic mutation in high hyperopia and microphthalmia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500095847
Enrollment
Unknown
Registered
2025-01-14
Start date
2025-01-15
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High degree of farsightedness

Interventions

sporadic:non-familial
familial:familial

Sponsors

Tianjin Medical University Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1. Patients with high hyperopia with spherical equivalent SE greater than or equal to +5.00D in the affected eye under cycloplegia; 2. The true microsphere is an axial AL less than 21mm;

Exclusion criteria

Exclusion criteria: 1. Have a clear history of organic disease, surgery or trauma in the eye; 2. Strabismus with astigmatism, myopia, and hyperopia; 3. Combined with systemic organic diseases or neurological diseases; 4. Those who are unable to complete specimen collection.

Design outcomes

Secondary

MeasureTime frame
refractive errors;axial length;

Primary

MeasureTime frame
mutations of MFRP, PRSS56, MYRF, TMEM98, CRB1, VMD2/BEST1;

Countries

China

Contacts

Public ContactHuaning

Tianjin Medical University Eye Hospital

tian2815@sina.com+86 18649001105

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026