Acute Respiratory Distress Syndrome
Conditions
Interventions
General protective lung ventilation group:The general protective lung ventilation strategy was used to meet the tidal volume of 6-8 ml/kg and the predicted body weight
plateau pressure is 25-30 cmH2O
driving pressure is less than or equal to 15 cmH2O.
Ultra-protective lung ventilation group:The ultra-protective lung ventilation strategy was used to meet the tidal volume less than or equal to 4 ml/kg and the predicted body weight
plateau pressure is less than or equal to 25 cmH2O
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients with moderate and severe ARDS(PaO2/FiO2?200mmHg) who were treated with ECMO and mechanical ventilation at the same time; (2) Age >= 18 years old; (3) Body mass index <= 35kg/m^2.
Exclusion criteria
Exclusion criteria: (1) Contraindications of EIT monitoring, such as unstable spinal or pelvic fractures, pacemaker installation, automatic implantable cardiac defibrillator, skin lesions between the fourth and fifth ribs, etc. (2) Pregnancy; (3) Severe respiratory acidosis; (4) Hemodynamic instability or restlessness; (5) Central venous catheterization is located in femoral vein; (6) Refusing to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilation blood flow ratio;Shunt rate;Dead space rate;Region of interest;End expiratory lung impedance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plateau pressure;Peak airway pressure;Lung compliance;Positive end-expiratory pressure; | — |
Countries
China
Contacts
Public ContactJunbo Zheng
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed