Alzheimer's disease
Conditions
Interventions
acupuncture and medication group:Tongdu Tiaoshen acupuncture combined with Donepezil hydrochloride tablets
Sponsors
Guangzhou Eighth People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. In line with the Alzheimer's Disease Dementia Working Group led by McKhann in the United States, published in 2011 by the National Institute on Aging (National Institute on Aging, NIA and the Association for Alzheimer's Disease, operational criteria for the diagnosis of Alzheimer's disease, Operational Criteria for the Diagnosis of Alzheimer's Disease, Operational Criteria for the Diagnosis of Alzheimer's Disease, Operational Criteria for the Diagnosis of Alzheimer's Disease, OCDAD) diagnostic criteria for Alzheimer's disease. 2. Age 45-85 years old; 3. The Chinese version of the simple mental state examination (MMSE) assessed cognitive impairment: illiterate group <=19 points, primary school group <=22 points, junior high school and senior high school group <=23 points, higher education group <=26 points; 4. Patients who are taking medications for cognitive impaitment other than donepezil hydrochloride that do not respond well or are ineffective. 5. Patients and their families have been informed in detail about the purpose, significance, expected effects and potential risks of this study. And voluntarily joined the trial, and signed the relevant informed consent.
Exclusion criteria
Exclusion criteria: 1. Other causes of cognitive impairment: cognitive impairment occurs or worsens within 3 months after definite stroke, or there are multiple infarcts or severe white matter high signal and other typical features of vascular dementia; Or have the core features of lewy body dementia such as fluctuating cognitive impairment, vivid visual hallucinations and spontaneous Parkinson's syndrome; Or have behavioral variation and frontal and/or anterior temporal lobe atrophy equal prominent features of frontotemporal dementia; Or other reversible causes such as hormonal or metabolic abnormalities, hypothyroidism, or folate/vitamin B12 deficiency; Or delirium or other mental and emotional disorders, such as schizophrenia, depression. 2. Patients with serious heart, liver, kidney, hematopoietic system diseases, systemic malnutrition. 3. Severe aphasia (difficulty in understanding, difficulty in expression), or severely reduced vision, blindness, or conscious disorders, or physical disorders can not cooperate with relevant tests. 4. People who have been using anticoagulants such as warfarin and heparin. 5. People with cardiac pacemakers; A severe fear of needles. 6. Patients who have been treated with this study protocol within the past 30 days. 7. Failure to complete the baseline evaluation process; No contact number, can not be accompanied by visitors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Mini-mental State Examination;Activity of Daily Living; | — |
Secondary
| Measure | Time frame |
|---|---|
| motor evoked potentials;Histone acetylase 3;Glycogen synthase kinase 3ß;Histone 3;Protein Kinase A;tumor necrosis factor;interleukin 1ß; | — |
Countries
China
Contacts
Public ContactLi Hongzhu
Guangzhou Eighth People's Hospital
Outcome results
None listed