insomnia,obstructive sleep apnea
Conditions
Interventions
healthy people group:none
COMISA-PAP treatment:none
COMISA-no PAP treatment:none
Sponsors
Wuxi people’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.With consent and a signed informed consent form, the participant agrees to complete the study as required by the protocol. 2.Age 18-70 years old, male and female; 3.In accordance with the Chinese Medical Association "Obstructive sleep apnea hypopnea diagnosis and therapeutic criteria", confirmed by polysomnography monitoring, and sleep apnea hypopnea index (AHI) AHI =5 times /h, Minimum oxygen saturation at night = 3 nights per week, plus significant daytime disturbance or distress in at least one area, under the conditions of adequate sleep time and appropriate sleep environment; 5.No mental illness, hearing and speech impairment, no history of sedatives and drug or alcohol dependence. 6.Specifically, patients in the insomnia group must meet criteria 1), 2), 4), and 5); patients in the OSA group must meet criteria 1), 2), 3), and 5); patients in the COMISA group must meet criteria 1), 2), 3), 4), and 5); and participants in the healthy control group must meet criteria 1), 2), and 5).
Exclusion criteria
Exclusion criteria: 1.Diagnosed with central or mixed sleep apnea, with central or mixed apnea accounting for =50%, or diagnosed with Cheyne-Stokes respiration. 2.Diagnosed with obesity hypoventilation syndrome or daytime hypercapnia. 3.Presence of respiratory or neuromuscular disorders deemed by the investigator to potentially interfere with study outcomes. 4.Acute infection, trauma, or major surgery within one month prior to screening. 5.Acute cardiovascular or cerebrovascular events within six months prior to screening. 6.History of malignant tumors within five years prior to screening, excluding carcinoma in situ. 7.Known or suspected history of substance abuse and/or alcoholism. 8.Presence or suspicion of severe depression, bipolar disorder, schizophrenia, suicidal tendencies, or other significant psychiatric disorders. 9.Inability to undergo cranial magnetic resonance imaging (MRI) due to physiological or psychological factors. 10.Use of intravenous glucocorticoids or stimulants such as modafinil within 14 days prior to screening. 11.Inability to complete questionnaire assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral magnetic resonance imaging (MRI);PSG; | — |
Countries
China
Contacts
Public ContactZhang Yunyun
Wuxi people’s Hospital
Outcome results
None listed