None
Conditions
Interventions
Experimental group :In the experimental group, patients took 200mg of celecoxib capsules orally 30 minutes before the operation.
Control group:In the control group, patients took 300mg of ibuprofen sustained-release capsules orally 30 minutes before the operation.
Sponsors
Beijing Shijingshan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Adult males and females aged between 18 and 40 years, with good physical health and no systemic diseases. 2. Patients with mandibular third molars that are mesioangularly impacted according to the Pell & Gregoey classification and mesially impacted according to the Winter classification, requiring gingival incision, flap elevation, bone removal, crown removal or root amputation. 3. With no history of allergy to non-steroidal anti-inflammatory drugs and acetaminophen. 4. Having not taken painkillers, anti-inflammatory drugs or anticoagulants within one week before tooth extraction. 5. The operation is completed within 30 - 40 minutes. 6. The patient signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. There are dental caries, periapical periodontitis, periodontitis or alveolar osteitis in the mandibular third molars and their adjacent teeth. 2. There are contraindications affecting tooth extraction, such as cardiovascular and cerebrovascular diseases, liver diseases and kidney diseases. 3. Non-experimental drugs are used for analgesia or anti-inflammation after tooth extraction. 4. There is a history of peptic ulcer or bleeding. 5. Special populations, including pregnant women, lactating women or patients with mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain scores;The usage situation of emergency analgesic drugs.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse Reaction Incidence Rate;MDAS score; | — |
Countries
China
Contacts
Public ContactMa Weiqing
Beijing Shijingshan Hospital
Outcome results
None listed