Postoperative Fatigue
Conditions
Interventions
Dexamethasone group:Open venous access is followed by 8 mg of dexamethasone
Dexamethasone combined with esketamine group:Open venous access is followed by 8 mg of dexamethasone.After induction, 0.25mg/kg esketamine was administered and the intraoperative rate of 0.125mg/kg/h
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective laparoscopic total hysterectomy; 2. ASA grade I - II; 3. Aged 18 to 65 years old; 4. BMI 18-30kg/m^2.
Exclusion criteria
Exclusion criteria: 1.The uterine lesion was malignant; 2.Patients with preoperative fatigue; 3. allergy and contraindications to dexamethasone drugs(Patients with active tuberculosis, thrombosis, gastric and duodenal ulcers, abnormal electrolyte metabolism, myocardial infarction, glaucoma; Patients with diabetes mellitus and poor glycemic control);4.Allergy and contraindication to esketamine; (Patients with severe elevation of intracranial pressure; People with untreated or poorly controlled high blood pressure; Patients with glaucoma; Patients with untreated or undertreated hyperthyroidism) 5.Complicated with severe cardiovascular disease (such as myocardial infarction, heart failure, malignant arrhythmia, Third-degree atrioventricular block, etc.), kidney disease (glomerular filtration rate =2mg/dl); 6. Those who were given any glucocorticoids 3 months before surgery; Recent antidepressant use or other antidepressant treatment;7.History of substance abuse, mental illness, communication disorders, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identity consequence fatigue scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Christensen fatigue score;Time from the end of the operation to extubation;Perioperative propofol, remifentanil consumption;Intraoperative vasoactive drug use;Incidence of postoperative nausea and vomiting;Remedial analgesics after surgery;VAS pain score;Pittsburgh Sleep Quality Index;The first time of the postoperative exhaust;Perioperative adverse reactions; | — |
Countries
China
Contacts
Public ContactGuanglei Wang
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed