Cleft lip and palate and cleft alveolar
Conditions
Interventions
Cleft lip and palate (high caries) Group A :None
Cleft lip and palate (low caries) Group B:None
Non-cleft lip and palate (high caries) Group A:None
Non-cleft lip and palate (low caries) Group B:None
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Test Group A: 1) Patients with cleft lip and palate (including cleft lip, cleft palate, cleft lip and palate, patients with cleft palate and cleft lip and palate with or without alveolar fissure, and included before or after bone grafting); 2) S(DMFS+dmfs) index: S>8; 3) Age 6-12 years old (including 6 years old and 12 years old), mixed dentition stage, good general health, psychomotor development in line with age; 4) Have not taken chronic medication or antibiotics in the past 3 months; 5) No salivary gland disease, no other oral diseases (such as periodontitis, mucosal disease); 6) Children who can cooperate with oral examination and saliva and plaque collection; 7) Informed consent of subjects and their parents or guardians. 2. Test Group B: 1) Patients with cleft lip and palate (including cleft lip, cleft palate, cleft lip and palate, patients with cleft palate and cleft lip and palate with or without alveolar fissure, and included before or after bone grafting); 2) S(DMFS+dmfs) index: 08 3) Age 6-12 years old (including 6 years old and 12 years old), mixed dentition stage, good general health, psychomotor development in line with age; 4) Have not taken chronic medication or antibiotics in the past 3 months; 5) No salivary gland disease, no other oral diseases (such as periodontitis, mucosal disease); 6) Children who can cooperate with oral examination and saliva and plaque collection; Informed consent of subjects and their parents or guardians. 4. Control group B: 1) Newly diagnosed patients in the Department of Endodontics, Preventive Dentistry, Pediatric Stomatology and Orthodontics of Shanghai Ninth People's Hospital; 2) S(DMFS+dmfs) index: 0<S<=8 3) Age 6-12 years old (including 6 years old and 12 years old), mixed dentition stage, good general health, psychomotor development in line with age; 4) Have not taken chronic medication or antibiotics in the past 3 months; 5) No salivary gland disease, no other oral diseases (such as periodontitis, mucosal disease); 6) Children who can cooperate with oral examination and saliva and plaque collection; 7) Informed consent of subjects and their parents or guardians.
Exclusion criteria
Exclusion criteria: 1) Systemic diseases (such as heart disease, diabetes, hypertension, etc.); 2) Developmental diseases, such as rickets, hyperpituitarism, anterior pituitary insufficiency, cretinism, acromegaly, Turner syndrome, etc.; 3) Salivary gland disease and other oral diseases, such as periodontitis and mucosal disease; 4) Taking chronic medication or antibiotics in the past 3 months; 5) Children who have undergone professional fluoride application in the past 3 months; 6) Children who are unable to cooperate with oral examination and saliva and plaque collection; 7) Refusal to sign informed consent or refusal to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DMFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| plaque index,PLI;Gingival index,GI; | — |
Countries
China
Contacts
Public ContactChen Zhenqi
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed