pemphigus vulgaris
Conditions
Interventions
Experimental group:None
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with mucosa-dominant pemphigus vulgaris by clinical, histopathological and immunological examination; 2. Aged 18 years and above; 3. Agreed to participate in the study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Women of childbearing age who are pregnant, breastfeeding, or have a pregnancy plan within 1 year; 2. Involvement of skin lesions occupying more than 1% of the body surface area; 3.Combination of other types of autoimmune skin diseases; 4.Patients who have recently received other immunosuppressive treatments; 5.Patients with severe cardiac, hepatic and renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| autoimmune bullous skin disorders intensity score (ABSIS);pemphigus disease area index (PDAI);pemphigus oral lesions area index (POLAI);oral disease severity score (ODSS);numerical rating scale (NRS);physician global assessment (PGA);Anti-Dsg1 level/Anti-Dsg3 leve; | — |
Secondary
| Measure | Time frame |
|---|---|
| complete remission on therapy;complete remission off therapy;remission;Glucocorticoid dosage; | — |
Countries
China
Contacts
Public ContactHongxia Dan
West China Hospital of Stomatology, Sichuan University
Outcome results
None listed