Depression
Conditions
Interventions
Intervention:CCT for the first 6 weeks (one hour per session, twice a week), followed by a 6-week observation period
Waitlist Control:a 6-week waitlist observation before starting CCT in the subsequent 6 weeks
Sponsors
Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: community-living Chinese individuals aged 60 years and older and having a primary diagnosis of major depressive disorder (single or recurrent episodes without psychotic features) based on the DSM-5 criteria, with moderate-to-severe depression (HAM-D total score >=17) and cognitive symptoms [Item 8 (slowness of thought and speech, impaired ability to concentrate) score >=2 in HAM-D], but without MCI or dementia (based on the age- and education-specific cutoff of HK-MoCA).
Exclusion criteria
Exclusion criteria: Individuals found to have active suicidal idea, psychotic symptoms, or treatment-resistant [history of electroconvulsive therapy, transcranial magnetic stimulation, or no clinical response to >=2 different classes of antidepressants] will be excluded and referred to the psychiatric services of the Hospital Authority. Other exclusion criteria are non-Chinese; living in care homes; having history or ongoing substance abuse (including alcohol), mania, bipolar or psychotic disorder, posttraumatic stress disorder, anxiety disorder, personality disorder, or mental disorder due to organic cause; having history of traumatic brain injury, Parkinson’s disease, stroke, dementia, or scoring below HK-MoCA cutoff; or having language barrier or impairment in communication (poor vision or hearing despite correction).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mood symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| PHQ-9;Global cognitive function; | — |
Countries
China
Contacts
Public ContactAllen Ting Chun Lee; Linda LAM
Chinese University of Hong Kong
Outcome results
None listed