Intraoperative hemodynamics, postoperative cognitive function
Conditions
Interventions
Experimental group (Group C):Cyclopofol 0.3~0.4mg/kg
Control group (P group):Propofol 1.5~2mg/kg
Sponsors
Henan Cancer Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Aged 65 years and above; (2) ASA I~II (3) Patients undergoing non-cardiac surgery under general anesthesia; (4) 18kg/m^2< BMI <30kg/m^2; (5) Patients or family members have fully understood the purpose and significance of this study, voluntarily participated in this study and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Those who are allergic to propofol or lipoemulsion; (2) Patients with psychiatric diseases (such as schizophrenia, depression, etc.), history of epilepsy and cognitive dysfunction; (3) Those with a history of abuse of psychotropic drugs and narcotics; (4) Communication impairment (language barrier, severe visual or hearing impairment); (5) ASA grade III or above, such as those with uncontrolled systemic diseases such as hypertension, diabetes, Patients with hyperthyroidism, severe cardiopulmonary diseases and abnormal liver function, kidney function and coagulation function Wait; (6) Participated in other drug clinical trials as a subject in the past 3 months; (7) Subjects who, in the opinion of the investigator, have any other factors that are not suitable for participating in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypotension during anesthesia;Bradycardia during anesthesia;Postoperative MMSE Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality;Postoperative recovery time; | — |
Countries
China
Contacts
Public ContactLu Xihua
Henan Cancer Hospital
Outcome results
None listed