Lower limb fractures
Conditions
Interventions
A Group:All elderly patients entered the pre-anesthesia room 30 minutes in advance, sprayed placebo normal saline from the nasal cavity, sprayed 1 spray into each nostril, stayed for about 30s, a tota
B Grop:All elderly patients entered the pre-anesthesia room 30 minutes in advance, sprayed dexmedetomidine from the nasal cavity, sprayed 1 spray into each nostril on both sides, stayed for about 30s,
C Group:All elderly patients entered the pre-anesthesia room 30 minutes in advance, sprayed dexmedetomidine from the nasal cavity, sprayed 1 spray into each nostril on each side, stayed for about 30 s
D Grop:All elderly patients entered the pre-anesthesia room 30 minutes in advance, sprayed dexmedetomidine from the nasal cavity, sprayed 1 spray into each nostril on both sides, stayed for about 30s,
Sponsors
Hainan Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: Elderly patients aged 65-75 years who have undergone major orthopaedic surgery; No contraindications to related medications; Preoperative family members sign the informed consent form for the trial.
Exclusion criteria
Exclusion criteria: Sinus bradycardia (<50 beats/min), atrioventricular block, sick sinus syndrome; allergy to narcotic drugs; Prior use of immunosuppressants and recent chemoradiotherapy; Current use of non-steroidal anti-inflammatory drugs or steroids, angiotensin-converting enzyme inhibitors, or bronchodilators; hepatic and renal insufficiency; epilepsy and related mental and cognitive dysfunction, long-term stress stimuli or psychological disorders; history of alcoholism, analgesic dependence, and long-term use of sedatives; Severe asthma, severe emphysema, severe bronchitis, severe chronic obstructive pulmonary disease, cardiac insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium conditions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Procalcitonin (PCT);Interleukin-6;Serum amyloid A (SAA);Intraoperative dose of sufentanil;Occurrence of intraoperative hypoxemia (SPO2<90%);Time to postoperative extubation;Incidence of nausea and vomiting at 24 hours postoperatively;Stress response; | — |
Countries
China
Contacts
Public ContactLin Jinyu
Hainan Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed